Combination of menin and kinase inhibitors as an effective treatment for leukemia with NUP98 translocations

Hongzhi Miao, Dong Chen, James Ropa, Trupta Purohit, EunGi Kim, Maria-Luisa Sulis, Adolfo Ferrando, Tomasz Cierpicki, Jolanta Grembecka

Leukemia, Nature Publishing Group UK London, 2024, pp. 1--14

Glucose Intolerance as a Consequence of Hematopoietic Stem Cell Dysfunction in Offspring of Obese Mice

Merve Denizli, James Ropa, Lindsay Beasley, Joydeep Ghosh, Kelli DeVanna, Taylor Spice, Laura S Haneline, Maegan Capitano, Kok Lim Kua

Molecular Metabolism, Elsevier, 2024, p. 102008

Protocol for enrichment and functional analysis of human hematopoietic cells from umbilical cord blood

Sarah Gutch, Lindsay Beasley, Scott Cooper, Mark H Kaplan, Maegan L Capitano, James Ropa

STAR protocols, vol. 5, Elsevier, 2024, p. 103024

The fulfilled promise and unmet potential of umbilical cord blood

James Ropa, Wouter Van’t Hof

Current Opinion in Hematology, vol. 31, LWW, 2024, pp. 168--174

Age-related decline in LEPR+ hematopoietic stem cell function

Thao Trinh, James Ropa, Scott Cooper, Arafat Aljoufi, Anthony Sinn, Maegan Capitano, Hal E Broxmeyer, Mark H Kaplan

Leukemia, vol. 37, Nature Publishing Group UK London, 2023, pp. 712--716

CXCL12/Stromal Cell-Derived Factor-1 and Hematopoiesis

Maegan L Capitano, James P Ropa, Hal E Broxmeyer

Elsevier, 2023

Insights into highly engraftable hematopoietic cells from 27-year cryopreserved umbilical cord blood

Hal E Broxmeyer, Larry L Luchsinger, Rona Singer Weinberg, Alexandra Jimenez, Emeline Masson Frenet, Wouter van’t Hof, Maegan L Capitano, Christopher D Hillyer, Mark H Kaplan, Scott Cooper, others

Cell Reports Medicine, vol. 4, Elsevier, 2023

CaMKK2 knockout bone marrow cells collected/processed in low oxygen (Physioxia) suggests CaMKK2 as a hematopoietic stem to progenitor differentiation fate determinant

Hal E Broxmeyer, James Ropa, Maegan L Capitano, Scott Cooper, Luigi Racioppi, Uma Sankar

Stem cell reviews and reports, vol. 18, Springer, 2022, pp. 2513--2521

Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects

Samisubbu R Naidu, Maegan Capitano, James Ropa, Scott Cooper, Xinxin Huang, Hal E Broxmeyer

Leukemia, vol. 36, Nature Publishing Group UK London, 2022, pp. 821--833

Leukemia inhibitory factor promotes survival of hematopoietic progenitors ex vivo and is post-translationally regulated by DPP4

James Ropa, Scott Cooper, Hal E Broxmeyer

Stem Cells, vol. 40, Oxford University Press US, 2022, pp. 346--357

Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal

Arafat Aljoufi, Chi Zhang, James Ropa, Wennan Chang, Lakshmi Reddy Palam, Scott Cooper, Baskar Ramdas, Maegan L Capitano, Hal E Broxmeyer, Reuben Kapur

Blood, The Journal of the American Society of Hematology, vol. 140, American Society of Hematology Washington, DC, 2022, pp. 1263--1277

Consequences of coronavirus infections for primitive and mature hematopoietic cells: new insights and why it matters

James Ropa, Thao Trinh, Arafat Aljoufi, Hal E Broxmeyer

Current Opinion in Hematology, vol. 28, LWW, 2021, pp. 231--242

CXCL15/Lungkine has suppressive activity on proliferation and expansion of multi-potential, erythroid, granulocyte and macrophage progenitors in S-phase specific manner

Hal E Broxmeyer, Scott H Cooper, James Ropa

Blood Cells, Molecules, and Diseases, vol. 91, Elsevier, 2021, p. 102594

Human hematopoietic stem, progenitor, and immune cells respond ex vivo to SARS-CoV-2 spike protein

James Ropa, Scott Cooper, Maegan L Capitano, Wouter Van’t Hof, Hal E Broxmeyer

Stem cell reviews and reports, vol. 17, Springer, 2021, pp. 253--265

Leptin receptor, a surface marker for a subset of highly engrafting long-term functional hematopoietic stem cells

Thao Trinh, James Ropa, Arafat Aljoufi, Scott Cooper, Anthony Sinn, Edward F Srour, Hal E Broxmeyer

Leukemia, vol. 35, Nature Publishing Group UK London, 2021, pp. 2064--2075

An expanded role for dipeptidyl peptidase 4 in cell regulation

James Ropa, Hal E Broxmeyer

Current opinion in hematology, vol. 27, LWW, 2020, pp. 215--224

Physioxia enhances T-cell development ex vivo from human hematopoietic stem and progenitor cells

Dong-Yeop Shin, Xinxin Huang, Chang-Hyun Gil, Arafat Aljoufi, James Ropa, Hal E Broxmeyer

Stem Cells, vol. 38, Oxford University Press, 2020, pp. 1454--1466

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation

James Ropa, Nirmalya Saha, Hsiangyu Hu, Luke F Peterson, Moshe Talpaz, Andrew G Muntean

Haematologica, vol. 105, Ferrata Storti Foundation, 2020, p. 2273

The PAF1c subunit CDC73 is required for mouse hematopoietic stem cell maintenance but displays leukemia-specific gene regulation

Nirmalya Saha, James Ropa, Lili Chen, Hsiangyu Hu, Maria Mysliwski, Ann Friedman, Ivan Maillard, Andrew G Muntean

Stem Cell Reports, vol. 12, Elsevier, 2019, pp. 1069--1083

p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

Talha Anwar, Caroline Arellano-Garcia, James Ropa, Yu-Chih Chen, Hong Sun Kim, Euisik Yoon, Sierrah Grigsby, Venkatesha Basrur, Alexey I Nesvizhskii, Andrew Muntean, others

Nature communications, vol. 9, Nature Publishing Group UK London, 2018, p. 2801